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SoHo is a neighborhood in the New York City borough of Manhattan. It is bounded roughly by Houston Street on the north, Lafayette Street on the east, Canal Street on the south, and Varick Street on the west.
The name is a blend of "South" and "Houston", from "south of Houston Street", and has no relation to the district called Soho in London, England. Its name is the model for other new neighborhood descriptions in New York City, such as TriBeCa and DUMBO. Before its incarnation as a trendy locale, it was known as the Cast Iron District.
It should be noted that Encyclopaedia Britannica's 1956 article on “New York (City)” states that the southern border of Greenwich Village is Spring Street. If Britannica was correct, SoHo may have encroached on the southern two blocks of the village’s traditional borders. This enabled it to be called “SoHo” (South of Houston) rather than “SoSp” (South of Spring).
Source: Wikipedia